Efficacy of co‑loading Ag nanoparticles and metronidazole in PEG–gelatin‑based sponges for the treatment of chronic wounds

Simple item page
dc.contributor.authorAlven, Sibusiso
dc.contributor.authorAdeyemi, S.A.
dc.contributor.authorUbanako, Philemon
dc.contributor.authorNditheh, D.T.
dc.contributor.authorChoonara, Yahya Essop
dc.contributor.authorAderibigbe, Blessing A.
dc.date.accessioned2025-10-10T12:49:49Z
dc.date.available2025-10-10T12:49:49Z
dc.date.issued2023-08-07
dc.description.abstractPolymer-based sponges loaded with antibacterial agents are potential wound dressings ideal for treating bacteria-infected wounds. Gelatin/poly (ethylene glycol) (PEG) sponge-based wound dressings loaded with metronidazole and Ag nanoparticles with different degrees of cross-linking were prepared, and their capability to treat infected wounds in vitro was evaluated. The degree of cross-linking of the sponges varied, and the porosity of the sponges was in the range of 15.64–91.10%. The amount of gelatin used to prepare the sponges influenced the porosity of the sponges. The sponges displayed an initial burst drug release of metronidazole followed by a sustained release profile. The sponges exhibited considerable antibacterial activity against Gram-positive and Gram-negative bacteria. The % cell viability of the sponges was in the range of 71.17–86.10%, indicating distinguished biocompatibility. The in-vitro experiment showed that the sponge loaded with metronidazole, SAM2%, displayed a significant reduction of 66.68% in the scratch area compared to the sponge loaded with a combination of silver nanoparticles and metronidazole with a closure rate of 46.61% at 96 h. The promising features of the sponges indicate that they are potential wound dressings for treating infected wounds.
dc.description.sponsorshipGovan Mbeki Research and Development Centre, (GMRDC), University of Fort Hare, South Africa Medical Research Council (SAMRC), and National Research Foundation (NRF), South Africa.
dc.identifier.citationAlven, S., Adeyemi, S. A., Ubanako, P., Ndinteh, D. T., Choonara, Y. E., & Aderibigbe, B. A. (2023). Efficacy of co-loading ag nanoparticles and metronidazole in PEG–gelatin-based sponges for the treatment of chronic wounds. Polymer Bulletin (Berlin, Germany), 81(6), 4819-4849. https://doi.org/10.1007/s00289-023-04915-1
dc.identifier.issn1436-2449
dc.identifier.urihttp://hdl.handle.net/20.500.11837/3261
dc.language.isoen
dc.publisherSpringer
dc.subjectInfected Wounds
dc.subjectWound Healing
dc.subjectAntibacterial Activity
dc.subjectBiopolymers
dc.subjectMetronidazole
dc.subjectMetal-based Nanoparticles
dc.titleEfficacy of co‑loading Ag nanoparticles and metronidazole in PEG–gelatin‑based sponges for the treatment of chronic wounds
dc.typeArticle
person.identifier.orcidAlven, Sibusiso 0000-0001-7100-4007
person.identifier.orcidAdeyemi, S.A. ?
person.identifier.orcidUbanako, Philemon 0000-0002-3281-8697
person.identifier.orcidNditheh, D.T. ?
person.identifier.orcidChoonara, Yahya Essop 0000-0002-3889-1529
person.identifier.orcidAderibigbe, Blessing A. 0000-0003-1157-7481

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Alven_S_EtAl_20230807_Chemistry.pdf
Size:
1.9 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Outputs