Efficacy of co‑loading Ag nanoparticles and metronidazole in PEG–gelatin‑based sponges for the treatment of chronic wounds
Date
2023-08-07
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
Polymer-based sponges loaded with antibacterial agents are potential wound dressings ideal for treating bacteria-infected wounds. Gelatin/poly (ethylene glycol) (PEG) sponge-based wound dressings loaded with metronidazole and Ag nanoparticles with different degrees of cross-linking were prepared, and their capability to treat infected wounds in vitro was evaluated. The degree of cross-linking of the sponges varied, and the porosity of the sponges was in the range of 15.64–91.10%. The amount of gelatin used to prepare the sponges influenced the porosity of the sponges. The sponges displayed an initial burst drug release of metronidazole followed by a sustained release profile. The sponges exhibited considerable antibacterial activity against Gram-positive and Gram-negative bacteria. The % cell viability of the sponges was in the range of 71.17–86.10%, indicating distinguished biocompatibility. The in-vitro experiment showed that the sponge loaded with metronidazole, SAM2%, displayed a significant reduction of 66.68% in the scratch area compared to the sponge loaded with a combination of silver nanoparticles and metronidazole with a closure rate of 46.61% at 96 h. The promising features of the sponges indicate that they are potential wound dressings for treating infected wounds.
Description
Keywords
Infected Wounds, Wound Healing, Antibacterial Activity, Biopolymers, Metronidazole, Metal-based Nanoparticles
Citation
Alven, S., Adeyemi, S. A., Ubanako, P., Ndinteh, D. T., Choonara, Y. E., & Aderibigbe, B. A. (2023). Efficacy of co-loading ag nanoparticles and metronidazole in PEG–gelatin-based sponges for the treatment of chronic wounds. Polymer Bulletin (Berlin, Germany), 81(6), 4819-4849. https://doi.org/10.1007/s00289-023-04915-1