The Potential of Antibiotics and Nanomaterial Combinations as Therapeutic Strategies in the Management of Multidrug-Resistant Infections: A Review

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dc.contributor.authorAdeniji, Oluwaseun Ola 0000-0003-4022-8109
dc.contributor.authorNontongana, Nolonwabo 0000-0002-8517-4274
dc.contributor.authorOkoh, Janet Chiyem
dc.contributor.authorOkoh, Anthony Ifeanyi 0000-0002-9770-085X
dc.date.accessioned2026-02-10T20:12:55Z
dc.date.available2026-02-10T20:12:55Z
dc.date.issued2022-11-30
dc.description.abstractAntibiotic resistance has become a major public health concern around the world. This is exacerbated by the non-discovery of novel drugs, the development of resistance mechanisms in most of the clinical isolates of bacteria, as well as recurring infections, hindering disease treatment efficacy. In vitro data has shown that antibiotic combinations can be effective when microorganisms are resistant to individual drugs. Recently, advances in the direction of combination therapy for the treatment of multidrug-resistant (MDR) bacterial infections have embraced antibiotic combinations and the use of nanoparticles conjugated with antibiotics. Nanoparticles (NPs) can penetrate the cellular membrane of disease-causing organisms and obstruct essential molecular pathways, showing unique antibacterial mechanisms. Combined with the optimal drugs, NPs have established synergy and may assist in regulating the general threat of emergent bacterial resistance. This review comprises a general overview of antibiotic combinations strategies for the treatment of microbial infections. The potential of antibiotic combinations with NPs as new entrants in the antimicrobial therapy domain is discussed.
dc.identifier.citationAdeniji, O.O.; Nontongana, N.; Okoh, J.C.; Okoh, A.I. The Potential of Antibiotics and Nanomaterial Combinations as Therapeutic Strategies in the Management of Multidrug-Resistant Infections: A Review. Int. J. Mol. Sci. 2022, 23, 15038. https://doi.org/ 10.3390/ijms232315038
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/20.500.11837/3678
dc.language.isoen
dc.publisherMDPI
dc.subjectmultidrug resistance
dc.subjectnanoparticles
dc.subjectantibiotic combinations
dc.subjectinfectious disease
dc.titleThe Potential of Antibiotics and Nanomaterial Combinations as Therapeutic Strategies in the Management of Multidrug-Resistant Infections: A Review
dc.typeArticle

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