Synthesis, characterization, and biological studies of pyrazolone Schiff bases and their transition metal complexes

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dc.contributor.advisorSadimenko, A Pen
dc.contributor.advisorAfolayan, A Jen
dc.contributor.authorIdemudia, Omoruyi Golden
dc.date.accessioned2026-08-12T23:53:33Z
dc.date.available2026-08-12T23:53:33Z
dc.date.issued2014en
dc.description.abstractSome new acylpyrazolone Schiff bases have been synthesized from the condensation reaction of two acylpyrazolone diketone precursors with phenylhydrazine, 2,4-dinitrophenylhydrazine and sulfanilamide. They have been fully characterized by elemental analysis and spectroscopic techniques (IR,1H and 13C NMR, and mass-spectra). The single crystal structure of the benzoyl derivative acylpyrazolone Schiff bases have been obtained and analyzed by X-ray crystallography technique. Solid state X-ray diffraction revealed a keto tautomer Schiff base in solid state. Mn(II), Co(II), Ni(II) and Cu(II) complexes with the Schiff bases have been synthesized and characterized by elemental analysis, IR and UV-VIS spectroscopy, magnetic susceptibility measurements, and thermal studies (TGA and DTG). An octahedral geometry around the transition metal ion, consisting of two bidentate Schiff base ligands bonding through the azometine nitrogen and ketonic oxygen have been proposed based on careful interpretation of available analytical and spectroscopic characterization results. Two water molecules as ligands complete the octahedral geometry in all cases. Using the invitro disc diffusion method for screening synthesized compounds against selected gram positive and gram negative bacterial at 40 mg/mL, and the DPPH free radical scavenging methods at 0.50, 0.25 and 0.13 mg/mL, the synthesized Schiff base and metal complexes showed varying biological activities. 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one sul29 fanilamide showed more activity generally, exhibiting a broad spectrum activity against all selected bacterial in some cases. Mn(II), Co(II) and Ni(II) complexes of sulfanilamide Schiff base with the acetylpyrazolone derivative 4-acetyl-3-methyl-1-phenyl-2-pyrazolin-5-one sulfanilamide, exhibited a stronger and very good DPPH radical scavenging activity as good as ascorbic acid on comparing, but not with Cu(II). As such they could be important antitumour candidates.en
dc.format263 leavesen
dc.formatpdfen
dc.identifier.citationIdemudia, Omoruyi Gold. 2014en
dc.identifier.othervital:11340en
dc.identifier.otherhttp://hdl.handle.net/10353/d1016068en
dc.identifier.urihttp://hdl.handle.net/20.500.11837/4580
dc.language.isoEnglishen
dc.publisherUniversity of Fort Hareen
dc.publisherFaculty of Science & Agricultureen
dc.rightsUniversity of Fort Hareen
dc.titleSynthesis, characterization, and biological studies of pyrazolone Schiff bases and their transition metal complexesen
dc.title.alternativeSynthesis, characterization, and biological studies of pyrazolone Schiff bases and their transition metal complexesen
dc.typeThesisen
dc.typeDoctoralen
dc.typePhD (Chemistry)en

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