Aladejana, E. B.Aladejana, A. E.2026-08-302026-08-302023Journal of Medicinal Plants for Economic Development, 7(1), a206http://hdl.handle.net/20.500.11837/5068Liver diseases pose a substantial global public health challenge, including liver failure, hepatitis, cirrhosis and associated complications. This systematic review examined the hepatoprotective activity of polyherbal formulations and their mechanisms of action. Electronic databases were searched for studies published between January 2010 and April 2023. Sixty-one articles showed that polyherbal formulations have significant activity against various hepatotoxic agents, including antioxidant, anti-inflammatory, antifibrotic and antiapoptotic effects. Some formulations also stimulated liver regeneration, enhanced bile secretion and promoted detoxification. Polyherbal formulations are a promising alternative to conventional treatments, but further work is needed to identify active compounds and clarify pharmacokinetics and pharmacodynamics.Article10.4102/jomped.v7i1.206